Cellular architecture of human skin lymphoma imaged by whole mount tissue microscopy. Normal human skin has a rich network of white blood cells (specifically dendritic cells, T cells and macrophages) which form sheaths around blood vessels. In diseased skin, such as in skin lymphoma as seen here, this normal architecture becomes distorted. In this image, lots of T cells (stained for CD3; red), dendritic cells (stained for CD11c; green) and macrophages (stained for LYVE-1; blue) have infiltrated the skin. X20 magnification. Scale bar (white) represents 100 micrometres.

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Cellular architecture of human skin lymphoma imaged by whole mount tissue microscopy. Normal human skin has a rich network of white blood cells (specifically dendritic cells, T cells and macrophages) which form sheaths around blood vessels. In diseased skin, such as in skin lymphoma as seen here, this normal architecture becomes distorted. In this image, lots of T cells (stained for CD3; red), dendritic cells (stained for CD11c; green) and macrophages (stained for LYVE-1; blue) have infiltrated the skin. X20 magnification. Scale bar (white) represents 100 micrometres. Dr. Xiao-nong Wang, Human Dendritic Cell Laboratory, Newcastle University. Attribution 4.0 International (CC BY 4.0). Source: Wellcome Collection.